The. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. Mouse Systems is not a household word, he told the journalist. About 10 minutes on the internet will show you those two gentlemen, who have appeared together, have been extensively fact checked for false or misleading claims or misuse of VAERS reporting and other data. By the beginning of September, he was no longer the companys CEO, replaced by his co-founder, Marten Nelson. Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. . In short, a lot of mumbo jumbo. 1 hr ago. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. One of the first CETF grants was to investigate the antimalarial hydroxychloroquine. Zero. There are other non-prescription things you should always have on hand. 1. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). While YouTube has repeatedly taken down the full video of the DarkHorse episode, various clips have been watched over 4 million times, and the full audio remains available on Spotify. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Who knows, Morris replied. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. Its not about the science. Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). are all super cheap, effective, and available without a prescription. He is very smart, and he knows that he is very smart, and hesometimes he behaves like he thinks hes the smartest guy in the room, whether he is or isnt, he told me. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Kirsch told me that meta-analyses are a higher level of evidence than randomized controlled trials. When I responded that meta-analyses are only as good as the data they are based on, he said Id like to understand your source on that, because I cant find a source that says a phase 3 trial is greater evidence than a meta-analysis., When you characterize me, you need to say that Steve Kirsch doesn't go with majority votes on interpreting data.. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. In September, he resigned as CEO and gave up his board seat. 533. The track management was so impressed, they asked for prescriptions. This is what the Seftel trial at Golden Gate fields used. Steve angrily decried this development as more evidence of FDA corruption. It has shown to be 100% protective of hospitalization in 2 clinical trials. Repurposed drugs are safer and more effective than the current vaccines. He started 7 high tech companies, two with billion dollar market caps. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. Can I see your risk-benefit analysis?. When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19? Medium banned him for misinformation. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. They knew in advance it was coming and on the day the paper was published they ignored it entirely. . . We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. The web price charge of skirsch.io . He may not be a good scientist, but hes smart, says WVUs Feinberg. If you cant lay off the java, then try fluoxetine (Prozac). In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. . The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. . So much for evidence-based medicine. Links to evidence about fluvoxamine including the public data repository. At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. Immediately after the results of the first fluvoxamine trial were releasedbut before they were published in a peer-reviewed journalhe wrote a post on Medium.com called The Fast, Easy, Safe, Simple, Low-Cost Solution to COVID That Works 100% of the Time That Nobody Wants to Talk About.. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. These huge businesses do often prioritize profits over human health: in 2009, Pfizer paid a $2.3 billion settlement over kickbacks and fraudulent marketing, including a $1.3 billion felony fine. But I know something else that few other people know, thanks to a source at the NIH: the NIH was planning to approve fluvoxamine months ago, but they got a call from the FDA telling them not to. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. This is quite stunning because the PK of the drug done at the Gates Foundation shows it only reaches 50% of the final concentration after 3 days. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. Steve and CETF funded the research that showed promising results of fluvoxamine as an early treatment of COVID-19. I have never heard of a case it didn't work. This advice is now outdated. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). Refresh. He has been a medical philanthropist for more than 20 years. So you can address your OCD and if you get COVID, youll can up the dose. The paramedics will think you are on drugs. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Has it really been 25 years, a whole quarter of a century? It could do nothing. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. My favorite dosage is 50mg twice a day for 14 days. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. The web value rate of skirsch.io is 2 . The NIH never did a risk benefit analysis of this drug. In-patient use. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. All the medical journals refused to publish the meeting notes (rejected by 6 journals). just like ivermectin). Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. All the supporting observational studies were positive as well. Most recent articles first. 95% confidence effect size is 75% or more. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. The next major effect is that that fluvoxamine activates the sigma-1 receptor. He wrote on his personal website that hed been advised that being associated with the drug would immediately trash my credibility.. 19 In addition, several . We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Fluvoxamine has at least a 30% hospitalization and death benefit. It could do nothing. Steve Kirsch. In other cases, stop cold turkey. Substitutions. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. . But the whole process has gone too slowly for Kirsch. Fluvoxamine, COVID, pandemic, . Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Steve Kirsch was extremely helpful early on in the pandemic, stepping up to fund early treatment trials when the US government would not fund such studies, Boulware told me in an email. The incident, he added, was completely in keeping with his personality.. Also, for people who cant tolerate fluvoxamine for whatever reason (nausea, jittery, etc), this is the alternative. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. We need to keep people out of the hospital in the first place. It is very important to educate doctors because most people rely on their doctors for advice. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. . CETF was founded by entrepreneur and philanthropist Steve Kirsch, as a way to expedite the fight against COVID-19. Steve Kirsch. Their willingness to lie did. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. The medical community did nothing (with a few exceptions like Dr. Seftel). No more. You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. Most doctors wont use it until NIH greenlights it, no matter what the science says. Always be self aware when using fluvoxamine. Steven Todd Kirsch is an American entrepreneur. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. No long haul symptoms if you start the drug ASAP after first symptoms. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. This document is a collection of evidence that highlights the glaring errors in our pandemic response. We didnt come up with better mouse technology than Microsoft did. February 17, 2021. . Here are my answers. In the early days of the pandemic, as billions of dollars poured into the hunt for novel treatments and vaccines, veteran Silicon Valley entrepreneur Steve Kirsch did what hes always done: He went looking for an underdog.

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